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Lab Members
Irina PINHEIRO

 

Irina Pinheiro

Postdoctoral Fellow

 

 

 

Biography

PhD in the lab from October 2012 until January 2017. Postdoctoral Fellow from January until March 2017.

2004-2008
Bachelor of Science degree in Genetics and Molecular Biology at Faculty of Science, University of Lisbon, Lisbon, PORTUGAL (3rd year done at Universitat de València, SPAIN via Erasmus/Socrates program).

2008-2010
Master in Developmental and Evolutionary Biology at Faculty of Science, University of Lisbon and Institute for Biotechnology and Bioengineering (IBB-CEBQ), Higher Technical Institute, Lisbon, PORTUGAL.

Internships

Master dissertation on "Non-viral gene delivery to stem cells" in Prof. Joaquim Cabral lab, supervised by Dr. Catarina Madeira, Institute for Biotechnology and Bioengineering (IBB-CEBQ), Higher Technical Institute, Lisbon, PORTUGAL (2009/2010).

Research Preparatory Course on "The role of Eph/Eprin signaling in cancer stem cells" in Assist. Prof. Ana Teixeira lab, Karolinska Institute, Department of Cell and Molecular Biology, Stockholm, SWEDEN (November 2010-June 2011).

Publications

Gene Delivery to human bone marrow mesenchymal stem cells by microporation.

Catarina Madeira*, Sofia C. Ribeiro, Irina S.M. Pinheiro, Sofia A.M. Martins, Pedro Z. Andrade, Cláudia L. da Silva, Joaquim M.S. Cabral. J Biotechnol. 2011 Jan 10;151(1):130-6.
PubMed

 

Laura SABOU

 

Laura Sabou

Undergraduate Student

Currently in her last year of M.Sc. at the Aberdeen University (Scotland)

 

 

Biography

September 2015 - August 2016: Long term internship, EMBL Monterotondo

2012 – Present: Degree of Master in Science in Biotechnology (Applied Molecular Biology) with Industrial Placement at University of Aberdeen, Aberdeen, Scotland

Internship

June-July 2015: Bachelor Internship looking at the cytotoxic effect of two anticancer drugs, treatment and analysis in the lab of Professor Timothy Smith, Division of Applied Medicine, University of Aberdeen, Aberdeen, Scotland.

Scholarships

Eramus+ Scholarship to perform research at EMBL Monterotondo (September 2015 - August 2016).


Ewa JANOSZ

 

Ewa Janosz

Postgraduate Student

Current doing her PhD at the Experimental Hematology group of Thomas Moritz at REBIRTH Cluster of Excellence, Hannover Medical School.

 

 

Biography

November 2015 - August 2016: Visiting Scientist, EMBL Monterotondo

2013 - 2015: MSc. Biotechnology, Jagiellonian University in Krakow, Faculty of Biochemistry, Biophysics and Biotechnology.

2010 - 2013: BSc. Biology, Jagiellonian University in Krakow, Faculty of Biology and Earth Sciences.

Internship

October 2013 - June 2015: MSc. internship in reprogramming of human fibroblasts into iPSCs and differentiation of iPSCs into cardiomyocytes in the group of Prof. Jozef Dulak, Department of Medical Biotechnology, Jagiellonian University in Krakow, Poland.

July - October 2014: Internship on Analysing the role of Erk in TGF-β induced epithelial to mesenchymal transition in the lab of Dr Vijay Tiwari, Institute of Molecular Biology, Mainz, Germany.

Scholarships

Erasmus Student Placement Scholarship to perform research at the Institute of Molecular Biology, Mainz, Germany (July - October 2014).


Kinga KOSIM

 

Kinga Kosim

Postgraduate Student

Currently Marie Curie Early Career Research (University of Sheffield, United Kingdom).

 

 

 

Biography

Visiting Scientist in the lab from January until December 2015.

2012 – 2014 Master of Science degree at University of Warsaw, Department of Applied Microbiology, Warsaw, Poland

2009 – 2012 Bachelor of Science degree at University of Warsaw, Department of Applied Microbiology, Warsaw, Poland

Internship

Partial studies abroad under the Erasmus programme. Molecular biology project: 'Purification of Nonribosomal Peptide Synthetase Adenylation Domains from Fusarium graminearum'. Department of Molecular Biology and Genetics, University of Aarhus, Denmark (January 2013 – June 2013)

Internship abroad under the Erasmus programme. Participated in the project: 'Evaluation of the infection-relevant role of small RNA-based regulatory system in the opportunistic pathogen Pseudomonas aeruginosa'. Department of Bioscience, University of Milan, Italy (October 2012 – December 2012)

Student placement, Department of Clinical Microbiology, Cancer Centre in Memorial of Maria Skłodowska-Curie, Warsaw, Poland (June 2011 – July 2011)

Publications

Activation of the TGFβ pathway impairs endothelial to haematopoietic transition

Özge Vargel, Yang Zhang, Kinga Kosim, Kerstin Ganter, Sophia Foehr, Yannicka Mardenborough, Maya Shvartsman, Anton J. Enright, Jeroen Krijgsveld and Christophe Lancrin.

Scientific Reports. 2016 Feb 19.

Jagielski, T., Kosim, K., Skora, M., Macura, A.B., Bielecki J. (2013). Identification of Scopulariopsis species by partial 28S rRNA gene sequence analysis, Polish Journal of Microbiology 62(3):303-306.


Christina NIKOLAKOPOULOU

 

Christina NIKOLAKOPOULOU

Postgraduate Student

Currently doing a MRes in Medical Mycology & Fungal Immunology, University of Aberdeen, Aberdeen, Scotland.

 

 

Biography

Internship in the lab from September 2014 until August 2015 (Third year M.Sc. project).

2011 – 2016: Degree of Master in Science in Molecular Biology with Industrial Placement at University of Aberdeen, Aberdeen, Scotland

Internship

June-July 2014: Bachelor Internship on the CRISP and STRIFE projects investigating stress resistance and host-pathogen interaction in the human fungal pathogen Candida albicans, in Fungal group of Professor Alistair Brown, School of Medical Sciences, University of Aberdeen, Aberdeen, Scotland.


Özge VARGEL

 

Özge VARGEL

Postdoctoral Fellow

Currently post-doctoral researcher at the Boston Children's hospital (USA).

 

Biography

PhD in the lab from January 2011 until July 2015.

2005-2010
Bachelor of Science degree at Bilkent University, Science Faculty, Molecular Biology and Genetics, Ankara, TURKEY

Internships

Senior project on the subject of "investigation of   regenerated liver on the search of adult liver stem cell" in Assist. Prof. Can Akcali's lab, Bilkent University, Molecular Biology and Genetics Department, Bilkent, Ankara, TURKEY (September 2009-May 2010).

Summer internship on the subject of "Species barrier on prion protein spreading of different yeast strands" in Prof. Yury Chernoff's lab, Georgia Institute of Technology, Molecular and Cell Biology Department, Atlanta, USA (June-August 2009).

Internship on the 'KANILTEK (Cancer Drug Technologies) Project' on the subject of "various kinase inhibitors and their potential as a cancer drug" in Assist. Prof. Rengul Cetin Atalay's lab, Bilkent University, Molecular Biology and Genetics Department, Bilkent, Ankara/TURKEY (January-May 2009).

Summer internship on the subject of "Biological functions of Raf kinase as a member of MAPK pathway" in Prof. Manuela Baccarini's lab, Vienna Biocenter, Max F. Perutz Laboratories, Vienna, AUSTRIA (July-August 2008).

Summer internship on the subject of  "gene mapping of inherited bipolar disorders" in Prof. Nurten Akarsu's lab,  Haccettepe University, Pediatric Hematology Department, Samanpazari, Ankara, TURKEY  (June-July 2007).

Publications

Activation of the TGFβ pathway impairs endothelial to haematopoietic transition

Özge Vargel, Yang Zhang, Kinga Kosim, Kerstin Ganter, Sophia Foehr, Yannicka Mardenborough, Maya Shvartsman, Anton J. Enright, Jeroen Krijgsveld and Christophe Lancrin.

Scientific Reports. 2016 Feb 19.

GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment.

Lancrin C, Mazan M, Stefanska M, Patel R, Lichtinger M, Costa G, Vargel O, Wilson NK, Möröy T, Bonifer C, Göttgens B, Kouskoff V, Lacaud G..
Blood.2012 Jun 5. [Epub ahead of print]
PubMed

Yannicka MARDENBOROUGH

 

Yannicka MARDENBOROUGH

Postgraduate Student

Internship in the lab from February until July 2014 (Fourth year B.Sc. project). Currently doing a PhD at the Department of Molecular Genetics, Erasmus MC, Rotterdam (The Netherlands).

 

 

Biography

2014 - 2016: MSc at the Department of Molecular Genetics, Erasmus MC, Rotterdam (The Netherlands)

2010 – 2014: Bachelor of Applied Science degree in Life Sciences at Hogeschool van Arnhem en Nijmegen, Nijmegen, The Netherlands.

Internship

Bachelor internship on the stimulation of zebrafish Relaxin Family Peptide Receptors (RXFPs) with human INSL3 in the group of Dr. Rüdiger Schulz, Department of Biology, Utrecht University, Utrecht, the Netherlands.

Publications

Dual daughter strand incision is processive and increases the efficiency of DNA mismatch repair

Nicolaas Hermans, Charlie Laffeber, Michele Cristovão, Mariela Artola-Borán, Yannicka Mardenborough, Pauline Ikpa, Aruna Jaddoe, Herrie H.K. Winterwerp, Claire Wyman, Josef Jiricny, Roland Kanaar, Peter Friedhoff, and Joyce H.G. Lebbink. Nucleic Acids Res. 2016 Aug 19; 44(14): 6770–6786.

Activation of the TGFβ pathway impairs endothelial to haematopoietic transition

Özge Vargel, Yang Zhang, Kinga Kosim, Kerstin Ganter, Sophia Foehr, Yannicka Mardenborough, Maya Shvartsman, Anton J. Enright, Jeroen Krijgsveld and Christophe Lancrin.

Scientific Reports. 2016 Feb 19.

 

Ana Cristina SANTOS

 

Ana Cristina SANTOS

EIPOD Postdoctoral Fellow

Post-doctoral research in the lab from February until September 2014.

 

 

Biography

Postdoctoral Research Assistant. Instituto Gulbenkian de Ciencia, Oeiras, Portugal. 2011-2013
Project: Epigenetic regulation of a distal enhancer in the mouse embryonic limb.
Supervisor: Moises Mallo
 
Postdoctoral Research Assistant. Wellcome Trust Centre for Human Genetics, University of Oxford, UK. 2011
Project: The role of iron homeostasis in cardiac function.
Supervisor: Ben Davies.

DPhil Student. WIMM, MRC Molecular Haematology Unit, University of Oxford, UK. 2005-2010
Project: Transcriptional regulation of Runx1 in the emerging mouse hematopoietic system.
Supervisor: Marella de Bruijn

Publications

Casaca, A.*, Santos, A.C.*, Mallo, M. (2013) Controlling Hox gene expression and activity to build the vertebrate axial skeleton. Dev. Dyn. 243:24-36.
*These authors have made equal contribution to this work.

Bee, T., Swiers, G., Muroi, S., Pozner, A., Nottingham, W., Santos, A. C., Li, P. S., Taniuchi, I., de Bruijn, M. F. (2010) Non redundant roles for Runx1 alternative promoters reflect their activity at discrete stages of developmental hematopoiesis. Blood 115:3042-50

Schiedlmeier, B., Santos, A. C., Ribeiro, A., Moncaut, N. Lesinski, D. Auer, H., Kornacker, K., Ostertag, W., Baum, C.,Mallo, M. and Klump, H. (2007) HOXB4's roadmap to stem cell expansion. Proc. Natl. Acad. Sci. USA 104:16952-16957

Cemre CELEN

 

Cemre CELEN

Postgraduate Student

Internship in the lab from September 2013 until January 2014 (Third year B.Sc. project). Currently doing her PhD at the University of Texas Southwestern (USA).

 

 

Biography

2010 – 2014: Bachelor of Science degree at Bilkent University, Science Faculty, Molecular Biology and Genetics, Ankara, Turkey.

Internships

Summer internship on the subject of " The role of Dlg5 gene in the indirect flight muscle development " in Dr. Frank Schnorrer's Lab, Max Planck Institute of Biochemistry, Munich, Germany (July-September 2013)

Senior project on the subject of "The half-life of FAM134B, a protein of unknown function which may be implicated in epithelial-to-mesenchymal transition (EMT), under different stimuli including EMT inducing TGF-β treatment in liver cancer cells" in Prof. Dr. Mehmet Ozturk's Lab, Bilkent University, Ankara, Turkey (September 2012 - June 2013)

Summer internship on the subject of " Investigation of novel genes implicated in skeletal dysplasia families " in Prof. Dr. Murat Günel's Lab, Yale University, School of Medicine, New Haven, CT, USA (August-September 2012)

Summer internship on the subject of " Test Activator and Repressor Function of En-SnaZf and VP16-SnaZf on Mesodermal and Ectodermal Enhancers "  in Prof. Dr. Maria Leptin`s Lab, University of Cologne, Institute of Genetics, Cologne, Germany (June-July 2012)

Summer internship in Prof. Dr. Mehmet Ozturk's Lab, Bilkent University (June-July 2011)

Scholarships

Amgen Scholars Program, funding to perform research at Ludwig Maximilians University of Munich. Includes housing, travel, and stipend (July-September, 2013)

Erasmus Student Placement Fellowship, funding to perform research at University of Cologne for 3 months (June-August, 2012)

TUBITAK (The Scientific and Technological Research Council of Turkey) Undergraduate Science Scholarship for students who have a degree in nationwide university exam  (2009-present)

Comprehensive Scholarship by Bilkent University (2009-present)

Publications

Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration.

Sun, X., Chuang, J.C., Kanchwala, M., Wu, L., Celen, C., Li, L., Liang, H., Zhang, S., Maples, T., Nguyen, L.H., Wang, S.C., Signer, R.A., Sorouri, M., Nassour, I., Liu, X., Xu, J., Wu, M., Zhao, Y., Kuo, Y.C., Wang, Z., Xing, C., and Zhu, H. (2016). Cell Stem Cell 18, 456–466.

 

 

Yang ZHANG

 

Yang ZHANG

Postgraduate Student

Internship in the lab from October 2012 until September 2013. Currently doing a PhD in the lab of Taija Mäkinen at the University of Uppsala (Sweden).

 

 

Biography

2009-2011
Master of Science, Nanobiophysics, BIOTEC, TU Dresden, Germany
 
2002-2006
Bachelor of Engineering, Bioengineering, The National Base of Life Science and Biotechnology Education, College of Life Sciences, Northwest Agriculture and Forestry University, China

Internships

Master project on "The study of the phosphorylation of HORMAD2 protein during meiosis of mouse", in Dr. Attila Toth lab, Institute of Physiological Chemistry, TU Dresden, Germany (October 2011 – November 2011).
 
Master project on "The study of the activation of proximodistal identity during regeneration of Axolotl", in Prof. Elly Tanaka lab, Center for Regenerative Therapies Dresden and Max Planck Institute of Molecular Cell Biology and Genetics, Germany (February 2011 – October 2011)
 
Master project on "Screening new regulators involved in regeneration of Zebrafish", in Dr. Christopher Antos lab, Center for Regenerative Therapies Dresden, Germany (February 2010 – January 2011)

Publications

cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels.

Lukas Stanczuk, Ines Martinez-Corral, Maria H. Ulvmar, Yang Zhang, Bàrbara Laviña, Marcus Fruttiger, Ralf H. Adams, Dieter Saur, Christer Betsholtz, Sagrario Ortega, Kari Alitalo, Mariona Graupera, and Taija Mäkinen. Cell Rep. 2015 Mar 10. pii: S2211-1247(15)00172-2. doi: 10.1016/j.celrep.2015.02.026.

Activation of the TGFβ pathway impairs endothelial to haematopoietic transition

Özge Vargel, Yang Zhang, Kinga Kosim, Kerstin Ganter, Sophia Foehr, Yannicka Mardenborough, Maya Shvartsman, Anton J. Enright, Jeroen Krijgsveld and Christophe Lancrin.

Scientific Reports. 2016 Feb 19.

Gülce PERÇIN

 

Gülce PERÇIN

Postgraduate Student

Internship in the lab from June 2013 until September 2013 (Third year B.Sc. project). Currently doing her PhD in the lab of Dr Claudia Waskow at the Technische Universität Dresden (Germany).

 

 

Biography

2010 – 2014: Bachelor of Science degree at Bilkent University, Science Faculty, Molecular Biology and Genetics, Ankara, Turkey.

2012-2013: Junior year at University of California, Santa Cruz Campus, Molecular, Cell and Developmental Biology, Santa Cruz, California, USA

Internships

Internship on the subject of "The effect of ATG1 and ATG2 proteins in biofuel formation in Chlamydomonas reinhardtii" in Assist. Prof Turgay Tekinay's Lab, Bilkent University , UNAM ,Bilkent, Ankara, TURKEY (September 2011- May 2012)

Summer Internship on the subject of "Construction of chromosomally integrated GFP-fusion nup107, rps2 and spi1 genes by using S. pombe" in Prof. Hiraoka Yasushi's Lab, Osaka University , Graduate School of Science, Osaka University , 1-1 Yamadaoka, Suita, Osaka, JAPAN.

Internship on the subject of "Dependence of ph05 transcription  levels based on the stochastic model for the chromatin transition" in Dr Hinrich Boeger's Lab, University of California Santa Cruz , California, USA (January –March 2013)

 

Ezgi BULCA

 

Ezgi BULCA

Postgraduate Student

Internship in the lab from June until September 2012 (Third year B.Sc. project with an Erasmus scholarship). Currently doing a PhD at the Max-Planck-Institut Für Psychiatrie (Germany).

 

 

Education

2013 - 2016: MSc in Neuroscience at the University of Bremen, Germany.

2009 - 2013: Bachelor of Science degree at Bilkent University, Science Faculty, Molecular Biology and Genetics, Ankara, Turkey.

Internships

Project on lightness and brightness processing in visual cortex in the group of Dr Hüseyin Boyacı, Bilkent University, Ankara, TURKEY (June-August 2011).

Project on TLR panels of mesenchymal stem cells (MSC) of mouse and effect of MSC on the immune response of mice in the group of Dr İhsan Gürsel (October 2009-July 2010).

Scolarship

Sept 2013-present Master in Neuroscience, University of Bremen, Bremen, GERMANY.

Sept 2009-2013 Bachelor of Science in Molecular Biology and Genetics, Bilkent University, Ankara, TURKEY

 

James DING

 

James DING

Undergraduate Student

Project in the lab from September 2011 until October 2012 for which James gained in March 2013 a Master of Science by Research at the University of Dundee (Scotland). Currently in his first year of PhD in the lab of Pr Jane Worthington at the University of Manchester (United Kingdom).

 

Education

2008-2011
Bachelor of Science degree in Biological Sciences (hons. Molecular Genetics) at the University of Edinburgh, Edinburgh, SCOTLAND

Internships

Project on cellular reprogramming in Prof. Ian Wilmut's lab, Scottish Centre for Regenerative Medicine, Edinburgh, SCOTLAND (February-May 2011).

Project on translation elongation in Dr Cathy Abbott's lab, Molecular Medicine Centre, Edinburgh, SCOTLAND (May-June 2010).

Project on carcinogenesis  in Pr Geoff Margison's lab, Paterson Institute for Cancer Research, Manchester, ENGLAND (June-August 2009 & July-September 2010).

 

Madhu ELANGO

 

Madhu ELANGO

Undergraduate Student

Internship in the lab from January until August 2012 (Master project). Currently in her first year of PhD at the Bharathiyar University (India).

 

Education

2010 - 2012
MS in Applied Biotechnology Uppsala University, Uppsala, SWEDEN

2005 - 2009
Bachelor of Engineering in Biotechnology NMAM Institute of Technology, Karkala Taluk, Karnataka, INDIA.

Internships

Project on microRNAs in Dr Donal O'Carrol's group, EMBL Mouse Biology Unit, Monterotondo, ITALY (September-December 2011).

Project on food packaging technology at the Central Food Research and Training Institute (CFTRI), Mysore, INDIA (July-August 2010).

Project on metabolomics at the Swedish Agricultural University (SLU), Uppsala, SWEDEN (March-May 2010).