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Christophe LANCRIN

 

Christophe Lancrin

Group Leader

Joint appointment: Developmental Biology Unit

EMBL Monterotondo, Adriano Buzzati-Traverso Campus, Via Ramarini 32, 00016 Monterotondo, Italy

E-mail: send a mail

 

 

Biography/Scientific Interests

During the course of my PhD research in developmental immunology in Paris, I have developed a strong interest in understanding the cell fate decisions occurring during differentiation. 

I carried on working on this aspect during my post-doc research in Manchester (UK) where I started to use embryonic stem cells to study the formation of blood progenitor and stem cells. This approach proved powerful to understand key biological events occurring in vivo but will also help to develop new methodologies for regenerative medicine. 

Since January 2011, I have started my research group at the European Molecular Biology Laboratory (EMBL) where I continue to explore cell fate decisions with a particular focus on how blood progenitors and stem cells are born from endothelial cells during embryonic development. 

Interdisciplinarity has become essential to push the boundary of knowledge in biology. EMBL is an institute composed of very diverse and highly qualified research groups. Therefore, I have access to a very strong set of experts in various fields: structural biology, proteomics, bioinformatics, genomics, cell biology, development biology and advanced imaging. This unique environment will allow me to combine different methodological and innovative approaches to address key questions such as how a cell changes identity.

Publications

Activation of the TGFβ pathway impairs endothelial to haematopoietic transition

Özge Vargel, Yang Zhang, Kinga Kosim, Kerstin Ganter, Sophia Foehr, Yannicka Mardenborough, Maya Shvartsman, Anton J. Enright, Jeroen Krijgsveld and Christophe Lancrin.

Scientific Reports. 2016 Feb 19.

GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1

Roshana*, Milena Mazan*, Rahima Patel, Victoria Moignard, Monika Stefanska, Elli Marinopoulou, Yaoyong Li, Christophe Lancrin, Thomas Clapes, Tarik Möröy, Catherine Robin, Crispin Miller, Shaun Cowley, Berthold Göttgens, Valérie Kouskoff and Georges Lacaud.

Nature Cell Biology. 2016 Jan;18:21-32. Epub 2015 Nov 30.
PubMed

*These authors contributed equally to the work.

GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment.

Lancrin C, Mazan M, Stefanska M, Patel R, Lichtinger M, Costa G, Vargel O, Wilson NK, Möröy T, Bonifer C, Göttgens B, Kouskoff V, Lacaud G..
Blood. 2012 Jul 12;120(2):314-22. Epub 2012 Jun 5.
PubMed

Identification and characterization of a novel transcriptional target of RUNX1/AML1 at the onset of hematopoietic development.

Cristina Ferreras, Christophe Lancrin, Michael Lie-A-Ling, Valerie Kouskoff and Georges Lacaud
Blood. 2011 Jul 21;118(3):594-7. Epub 2011 Apr 15.
PubMed

The sequential expression of CD40 and Icam2 defines progressive steps in the formation of blood precursors from the mesoderm germ layer.

Pearson, S.,Lancrin, C., Lacaud, G. & Kouskoff, V.
Stem Cells. 2010 Jun;28(6):1089-98.
PubMed

The differential activities of Runx1 promoters define milestones during embryonic hematopoiesis.

Sroczynska, P., Lancrin, C., Kouskoff, V. & Lacaud, G.
Blood. 2009 Dec 17;114(26):5279-89. Epub 2009 Oct 26.
PubMed

Blood cell generation from the hemangioblast.

Lancrin, C., Sroczynska, P., Serrano, A.G., Gandillet, A., Ferreras, C., Kouskoff, V. & Lacaud, G.
J Mol Med. 2010 Feb;88(2):167-72. Epub 2009 Oct 25.
PubMed

Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program.

Hoogenkamp, M., Lichtinger, M., Krysinska, H., Lancrin, C., Clarke, D., Williamson, A., Mazzarella, L., Ingram, R., Jorgensen, H., Fisher, A., Tenen, D.G., Kouskoff, V., Lacaud, G. & Bonifer, C.
Blood. 2009 Jul 9;114(2):299-309. Epub 2009 Apr 1.
PubMed

The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage.

Lancrin, C., Sroczynska, P., Stephenson, C., Allen, T., Kouskoff, V. & Lacaud, G.
Nature. 2009 Feb 12;457(7231):892-5. Epub 2009 Jan 28.
PubMed

Extrathymic hemopoietic progenitors committed to T cell differentiation in the adult mouse.

Arcangeli, M.L., Lancrin, C., Lambolez, F., Cordier, C., Schneider, E., Rocha, B. & Ezine, S.
J Immunol. 2005 Feb 15;174(4):1980-8.
PubMed

Major T cell progenitor activity in bone marrow-derived spleen colonies.

Lancrin, C., Schneider, E., Lambolez, F., Arcangeli, M.L., Garcia-Cordier, C., Rocha, B. & Ezine, S.
J Exp Med. 2002 Apr 1;195(7):919-29.
PubMed

 

Kerstin GANTER

 

Kerstin Ganter

Research Technician

EMBL Monterotondo, Adriano Buzzati-Traverso Campus, Via Ramarini 32, 00016 Monterotondo, Italy

E-mail: send a mail

 

 

Biography

At EMBL Monterotondo since January 2011

Research & Development "Microarray-Technology". Febit Biomed gmbH, Heidelberg, GERMANY (2007–2010).

Research in HIV. Virology Department, University Clinic, Heidelberg, GERMANY (2004–2007).

Asthma - and Allergy Genetics. ZKF at University Children ́s Hospital, Freiburg, GERMANY (2002–2004).

Tropical Medicine. Research project of the Bernhard-Nocht-Institute, KCCR Kumasi, GHANA (2001–2002).

GMO-Analytics. GeneScan Europe AG, Freiburg, GERMANY (2000–2001).

Plant Molecularbiology. Plant Biotechnology, University, Freiburg, GERMANY (1999–2000).

Publications

Activation of the TGFβ pathway impairs endothelial to haematopoietic transition

Özge Vargel, Yang Zhang, Kinga Kosim, Kerstin Ganter, Sophia Foehr, Yannicka Mardenborough, Maya Shvartsman, Anton J. Enright, Jeroen Krijgsveld and Christophe Lancrin.

Scientific Reports. 2016 Feb 19.

Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo.

Michel N, Goffinet C, Ganter K, Allespach I, Kewalramani VN, Saifuddin M, Littman DR, Greene WC, Goldsmith MA, Keppler OT.
Retrovirology. 2009 Jan 13;6:2.
PMID: 19144136 [PubMed - indexed for MEDLINE] Free PMC Article
PubMed

Microfluidic-based enzymatic on-chip labeling of miRNAs.

Vorwerk S, Ganter K, Cheng Y, Hoheisel J, Stähler PF, Beier M.
N Biotechnol. 2008 Oct-Dec;25(2-3):142-9. Epub 2008 Aug 20.
PMID: 18786664 [PubMed - indexed for MEDLINE]
PubMed

The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling.

Michel N, Ganter K, Venzke S, Bitzegeio J, Fackler OT, Keppler OT.
Mol Biol Cell. 2006 Aug;17(8):3578-90. Epub 2006 Jun 14.
PMID: 16775006 [PubMed - indexed for MEDLINE] Free PMC Article
PubMed

Polymorphisms of the TGF-beta1 gene are not associated with bronchial asthma in Caucasian children.

Heinzmann A, Bauer E, Ganter K, Kurz T, Deichmann KA.
Pediatr Allergy Immunol. 2005 Jun;16(4):310-4.
PMID: 15943594 [PubMed - indexed for MEDLINE]
PubMed

Association study of the IL13 variant Arg110Gln in atopic diseases and juvenile idiopathic arthritis.

Heinzmann A, Jerkic SP, Ganter K, Kurz T, Blattmann S, Schuchmann L, Gerhold K, Berner R, Deichmann KA.
J Allergy Clin Immunol. 2003 Oct;112(4):735-9.
PMID: 14564352 [PubMed - indexed for MEDLINE]
PubMed

 

Yasmin SERINA SECANECHIA

 

Yasmin Serina Secanechia

Predoctoral Fellow

EMBL Monterotondo, Adriano Buzzati-Traverso Campus, Via Ramarini 32, 00016 Monterotondo, Italy

E-mail: send a mail

 

 

Biography

At EMBL Monterotondo since March 2017

October 2013 - March 2016
MSc Molecular and Cellular Medical Biotechnologies, Università Vita-Salute San Raffaele, Milan, Italy

October 2010 - November 2013
BSc in Medical and Pharmaceutical Biotechnologies, Università Vita-Salute San Raffaele, Milan, Italy

Internship

Research project on “Studying clonal dynamics of hematopoietic reconstitution and vector-induced oncogenesis in mouse models of hematopoietic stem cell-gene therapy by longitudinal vector integration site analyses”, in the group of Dr. Eugenio Montini, San Raffaele Telethon Institute for Gene Therapy (SR-TIGET) - Division of regenerative medicine, stem cells and gene therapy - San Raffaele Hospital, Milan, Italy (September 2014 - March 2017).

Publication

Safety and Efficacy of Retroviral and Lentiviral Vectors for Gene Therapy.

Daniela Cesana, Monica Volpin, Yasmin Natalia Serina Secanechia & Eugenio Montini. 2017. Chapter in the book "Safety and Efficacy of Gene-Based Therapeutics for Inherited Disorders". DOI 10.1007/978-3-319-53457-2_2.

 

Artem ADAMOV

 

Artem ADAMOV

Undergraduate Student

EMBL Monterotondo, Adriano Buzzati-Traverso Campus, Via Ramarini 32, 00016 Monterotondo, Italy

E-mail: send a mail

 

 

Biography

Since January 2019 - Long term internship, EMBL Rome

2018 – Present: Degree of Master in Bioinformatics at the Moscow Institute of Physic and Technology (State University), Moscow, Russia

2014 – 2018: B.Sc in Applied Mathematics and Physics at the Moscow Institute of Physic and Technology (State University), Moscow, Russia


Léa BOUILLEAU

 

Léa Bouilleau

Postgraduate Student

EMBL Monterotondo, Adriano Buzzati-Traverso Campus, Via Ramarini 32, 00016 Monterotondo, Italy

E-mail: send a mail

 

 

Biography

Since January 2020 - Long term internship, EMBL Rome

2018 - 2020: Master’s degree in Biology and Health at the University of Rouen, France

2015 - 2018: Bachelor’s degree in Biochemistry, Molecular, Cellular Biology and Physiology at the University of Rouen, France.

Scholarships

Eramus+ Scholarship to perform research at EMBL Rome (January 2020 - June 2020)


Ilyess RACHEDI

 

Ilyess Rachedi

Postgraduate Student

EMBL Monterotondo, Adriano Buzzati-Traverso Campus, Via Ramarini 32, 00016 Monterotondo, Italy

E-mail: send a mail

 

 

Biography

Since January 2020 - Long term internship, EMBL Rome

2017 - 2020: Master’s degree in Bioinformatics, Software Development and Data Analysis at the University of Aix-Marseille, France

2014 - 2017: Bachelor's degree in Biology, Pathology Cell Biology at the University of Aix-Marseille, France.

Scholarships

Eramus+ Scholarship to perform research at EMBL Rome (January 2020 - June 2020)


Chrysi KAPSALI

 

Chrysi Kapsali

Undergraduate Student

EMBL Monterotondo, Adriano Buzzati-Traverso Campus, Via Ramarini 32, 00016 Monterotondo, Italy

E-mail: send a mail

 

 

Biography

Since November 2019 - Long term internship, EMBL Rome

2014 - 2019: Bachelor’s degree in Biology at the Aristotle University of Thessaloniki, Greece